How to edit and set properties and permissions for a registry value?

Use the [ Properties ] toolbar button, the "Properties..." tree context menu item, the "Modify..." list context menu item, or press the Enter key while the focus is on a value in the "Values" panel.
You can choose to create the selected registry key when your package is being installed - if this key doesn't exist on the target machine. Also, you can choose to delete the selected key at Uninstall.
The Path to the key is localizable.
Removal
You can specify the key to be removed upon install from the Registry Key Removal Dialog.
Permissions
Clicking on the "Permissions" tab will allow you to set the registry value's Permissions.
Note: You should do this at your own risk, if you don't know anything about computer performence that would be a good indication of don't touch.
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